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Nutrition and Autoimmune Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 1627

Special Issue Editors


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Guest Editor
Department of Human Pathology of Adulthood and Childhood DETEV "G. Barresi", Endocrinology Unit, University of Messina, 98125 Messina, Italy
Interests: oxidative stress; antioxidants; autoimmunity; autoimmune diseases; immunonutrition; inflammation; mediterranea diet; functional foods and supplements (e.g., vitamins, minerals, plant bioactive compounds); thyroid diosrders; neuroendocrine tumors

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Guest Editor

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Guest Editor
Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Interests: cellular biochemistry; nutraceuticals; neurodegeneration; oxidative stress; inflammation; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autoimmune diseases (AIDs) result from a failure of immunological tolerance to self-antigens and the consequent activation of immune responses against self-tissues, with consequent tissue damage and loss of function. The prevalence of AIDs has been steadily increasing in recent decades, and about 4% of the general population worldwide has at least one autoimmune disease, with women being more affected than men. The pathogenesis is not understood completely, but is largely due to the interaction between genetic and environmental factors. In particular, changes in our exposure to environmental triggers are deemed to play crucial roles in such a rise in autoimmunity and are mainly observed in richer and more industrialized societies. Among these, nutritional factors appear to be of increasing importance. Nutritional status is closely associated with immunity and host resistance to infection, and the interconnection between nutrition and the immune system has been an area of growing interest in recent years.

The complexity of the interaction between nutrition and immunology is vast. An individual’s overall nutrition status, state of nourishment, and pattern of food intake (comprising foods, nutrients, and non-nutritive bioactive compounds) impact the immune system’s function; this impact can occur at the level of physical barriers (e.g., the skin and intestinal mucous membranes), the microbiome, the innate immune system (e.g., macrophage function and polarization), and the adaptive immune system (e.g., T- and B-cell function). Conversely, the immune system impacts nutrition metabolism and needs, and influences the physiological response to food.

This Special Issue welcomes manuscripts involving preclinical and clinical research, observational and meta-analysis studies, and analytical reviews focused on the role of nutrition in the immune response, autoimmunity, and potential nutritional strategies to manage autoimmune diseases.

Dr. Rosaria Maddalena Ruggeri
Prof. Dr. Silvana Hrelia
Dr. Maria Cristina Barbalace
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune diseases
  • nutrition
  • immune system
  • inflammation
  • oxidative stress
  • microbiota
  • nutraceuticals

Published Papers (1 paper)

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Research

13 pages, 730 KiB  
Article
The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank
by Camilla Barbero Mazzucca, Lorenza Scotti, Cristoforo Comi, Domizia Vecchio, Annalisa Chiocchetti and Giuseppe Cappellano
Nutrients 2024, 16(11), 1746; https://doi.org/10.3390/nu16111746 - 2 Jun 2024
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Abstract
Multiple sclerosis (MS) is a debilitating autoimmune condition primarily affecting young adults, and its rise is evident globally. Despite this, its precise etiology remains elusive. Both genetic and environmental factors contribute to MS susceptibility; however, the link between diet and MS lacks substantial [...] Read more.
Multiple sclerosis (MS) is a debilitating autoimmune condition primarily affecting young adults, and its rise is evident globally. Despite this, its precise etiology remains elusive. Both genetic and environmental factors contribute to MS susceptibility; however, the link between diet and MS lacks substantial evidence due to limited large-scale studies. We exploited the UK Biobank resources to explore the nexus between diet, lifestyle, and MS risk. The dietary and lifestyle habits of MS incident cases, derived from a general food frequency questionnaire (FFQ) completed by all participants at study enrollment, were compared to those of subjects who did not develop MS during the follow-up. Our findings suggest the protective role of moderate oily fish consumption and weekly alcohol intake. Furthermore, by analyzing food intake data obtained through 24 h recall, completed by a subset of participants, we found a protective, though non-significant, trend of an increased adherence to the Mediterranean diet (MD). These findings, derived from the analysis of the UK Biobank and representing an unprecedented approach for this inquiry, warrant further exploration and integration in future research. Full article
(This article belongs to the Special Issue Nutrition and Autoimmune Diseases)
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