Cancer Gene Therapy with Non-viral Nanocarriers, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 370
Special Issue Editors
Interests: nanotechnology; liposomes; nanoemulsion; model lipid membranes; drug targeting
Special Issues, Collections and Topics in MDPI journals
Interests: molecular pharmacology/biology; gene therapy; clinical pharmacology; toxicology; determination of molecular mechanisms of cardiovascular and metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Interests: pharmaceutical technology; nanotechnology; gene delivery; liposomes, nanocarrier development and characterization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is currently affecting millions of people worldwide and is considered to be one of the leading causes of death in the world. Conventional therapies for cancer treatment include surgery, radiotherapy and chemotherapy, but these interventions often cause severe side effects within patients due to their lack of specificity. As a result, new therapeutic treatments are needed which have an improved efficacy and reduced toxicity. One of these potential treatments is gene therapy, which aims to deliver genetic material to cancer cells in order to reduce or eliminate a tumor or repair errors that cause cells to become cancerous in an attempt to reverse their state. Various gene therapy approaches are used for cancer treatment, including the replacement/correction of missing or defective genes to suppress tumor formation, the modulation of the immune system to recognize cancer cells, silencing of oncogenes to suppress the formation or spreading of cancer, the use of suicide genes that cause the self-destruction of cancer cells, the use of antiogenetic genes to prevent tumor blood vessels from forming and the use of genes that increase the sensitivity of cancer cells to conventional therapies or protect healthy cells from them. The successful implementation of gene therapy requires carriers that can protect the genetic material and efficiently deliver it (alone or in combination with conventional therapeutics) specifically to cancer cells. Various delivery systems have been developed and studied, including viral vectors and non-viral systems, such as lipoplexes, polyplexes and inorganic nanoparticles. Non-viral vectors present various advantages such as their safety, low cost and ability to carry larger genetic materials, and they can be designed with specific properties.
For this Special Issue of Pharmaceutics, we invite researchers to submit original research articles focused on novel gene delivery strategies for cancer treatment using non-viral nanocarriers; these may include new genes or gene/conventional therapeutics combinations delivered with non-viral nanocarriers or new non-viral nanocarriers. Review articles on the latest advancements made in the above-mentioned areas are also welcome.
Dr. Sophia Hatziantoniou
Dr. Eleftheria Galatou
Dr. Elena Mourelatou
Guest Editors
Manuscript Submission Information
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Keywords
- nanocarriers
- gene delivery
- lipoplexes
- polyplexes
- non-viral vectors
- cancer therapy
- transfection
Related Special Issue
- Cancer Gene Therapy With Non-Viral Nanocarriers in Pharmaceutics (7 articles)
