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Photonics
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Development and Application of Optical Coherence Tomography in the Context...
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Development and Application of Optical Coherence Tomography in the Context of Other Biophotonics Techniques

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: closed (1 June 2023) | Viewed by 5379

Special Issue Editors

Prof. Vladimir Y. Zaitsev

E-Mail Website
Guest Editor
Institute of Applied Physics, Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia
Interests: optical coherence tomography; multimodal OCT; optical coherence angiography; optical coherence elastography; tissue biomechanics; OCT-based biopsy
Dr. Elena Kiseleva

E-Mail Website
Guest Editor
Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Sq., Nizhny Novgorod, 603950 Russia
Interests: multimodal optical coherence tomography (OCT); diagnostics of oncological; inflammatory and ischemic processes; laparoscopic OCT diagnostics; glioma models; myelin condition; FLIM-macroimaging; image quantification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Optical Coherence Tomography (OCT) celebrated its 30-year anniversary in 2021. OCT has proven to be one of the most rapidly develo** techniques of biomedical visualization, including rather fast translation for clinical applications, especially in ophthalmology, where OCT has already become a “gold standard” diagnostic method. In the last decade, significant progress has also been demonstrated in the development of new OCT modalities and clinical applications of multimodal OCT-based imaging, including such extensions as polarization-sensitive OCT, OCT-based angiography (OCA), dynamic-contrast OCT, and the rapidly develo** Optical Coherence Elastography (OCE). Methods of obtaining new important biomedical information based on deep analysis of OCT-scan texture, machine learning, etc., also demonstrate very interesting prospects. These new extensions open unprecedented perspectives for utilization in problems of oncology, gynecology, and other areas, where OCT demonstrates abilities to a significant degree substitute conventional histology. Comparison with other methods of biomedical visualization deeper reveals unique abilities of various OCT modalities.  The present Special Issue aims to emphasize the recent progress in both physical aspects of the development of OCT and demonstrations of its new biomedical applications in the context of other diagnostic methods.

In view of the ever-growing interest in the development of Optical Coherence Tomography, the rapid emergence of new OCT modalities, comprising both physical aspects of the OCT-based methods and demonstrations of new biomedical applications OCT, this MDPI Editorial brings to your attention the planned Special Issue of MDPI Photonics entitled “Development and Application of Optical Coherence Tomography in the context of other biophotonics techniques”.

Bearing in mind your expertise and research activity, we are pleased to invite you to contribute your research results to the above-mentioned Special Issue.  Both original research articles and reviews are welcome. The research areas may include both physical developments of various OCT-based modalities, as well as demonstrations of their applications for a broad range of biomedical applications according to your current interests, including comparative studies of OCT and other diagnostic techniques.  

Depending on the possibilities and approval of MDPI, reductions in the standard article processing fees for the publication of high-quality research may be possible for this Special Issue.  We look forward to receiving your contributions.

Prof. Vladimir Y. Zaitsev
Dr. Elena Kiseleva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography
  • multimodal OCT
  • optical coherence angiography
  • optical coherence elastography
  • optical biopsy
  • biomedical diagnostics
  • image quantification

Published Papers (4 papers)

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Research

12 pages, 9530 KiB  
Communication
Evaluation of Renal Ischemia–Reperfusion Injury Using Optical Coherence Tomography Based on Fractal Dimension
by Yuhong Fang, Wei Gong, Zheng Huang, Yongtao Zhang, Limin Zhang and Shusen **e
Photonics 2023, 10(7), 741; https://doi.org/10.3390/photonics10070741 - 28 Jun 2023
Viewed by 773
Abstract
Renal ischemia–reperfusion (IR) is inevitable in partial nephrectomy and kidney transplantation. Acute tubular necrosis (ATN) induced by renal IR causes the loss of functional units in the kidney, pathologically presenting as the nonhomogeneous distribution of normal uriniferous tubules and usually used to characterize [...] Read more.
Renal ischemia–reperfusion (IR) is inevitable in partial nephrectomy and kidney transplantation. Acute tubular necrosis (ATN) induced by renal IR causes the loss of functional units in the kidney, pathologically presenting as the nonhomogeneous distribution of normal uriniferous tubules and usually used to characterize kidney activity. Optical coherence tomography (OCT) has been proven to have the ability to image the kidney microstructure in vivo and in real time. However, a fast image analysis method is needed for clinical application purpose. In this work, a new method for assessing renal IR injury was developed using a fractal-dimension-based texture of the OCT kidney image. Thirty-five Wistar rats were divided into seven groups for renal ischemia–reperfusion: control and various ischemia-time groups. A time series of 3D OCT kidney images was obtained. We calculated the fractal dimension (FD) of OCT en face images and found that the value increased gradually and finally became stable after 90 min of reperfusion. The stable value in the long-ischemia-time group was smaller than that in the short-ischemia-time group. The FD value of the OCT kidney image was highly responsive to renal IR injury. The proposed method is promising for a fast diagnostic application. Full article
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography in the Context of Other Biophotonics Techniques)
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14 pages, 6330 KiB  
Article
Motion Artifact Suppression Method for the Clinical Application of Otoscopic Spectral-Domain Optical Coherence Tomography
by Sergey Y. Ksenofontov, Pavel A. Shilyagin, Valentin M. Gelikonov and Grigory V. Gelikonov
Photonics 2023, 10(7), 736; https://doi.org/10.3390/photonics10070736 - 27 Jun 2023
Viewed by 686
Abstract
A compact OCT device and a method for image reconstruction are described. The proposed algorithm contains a novel procedure for motion artifact suppression based on a correction of the phase of the original interferometric signal due to the mutual correlation of adjacent A-scans. [...] Read more.
A compact OCT device and a method for image reconstruction are described. The proposed algorithm contains a novel procedure for motion artifact suppression based on a correction of the phase of the original interferometric signal due to the mutual correlation of adjacent A-scans. This procedure corrects distortions caused by unwanted displacements of the probe relative to the object in real time at a speed of up to 3 mm/s and an image acquisition rate of 20 B-scans per second. All processing is performed in real time using only the CPU, allowing the device to be controlled from a consumer-grade laptop or compact PC without the need for a discrete GPU. Due to its compact size, the device can be used in the conditions of an ENT examination room or operating room and can be freely moved to another room without the help of additional personnel, if necessary. Full article
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography in the Context of Other Biophotonics Techniques)
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14 pages, 4160 KiB  
Article
Evaluation of Residual Corneal Stromal Bed Elasticity by Optical Coherence Elastography Based on Acoustic Radiation Force
by Yidi Wang, Yubao Zhang, Gang Shi, Sizhu Ai, Guo Liu, **ao Han and **ngdao He
Photonics 2023, 10(3), 266; https://doi.org/10.3390/photonics10030266 - 2 Mar 2023
Cited by 3 | Viewed by 1373
Abstract
Despite the rapidly growing popularity of laser vision correction (LVC) in the correction of myopia, its quantitative evaluation has not been thoroughly investigated. In this paper, an acoustic radiation force–optical coherence elastography (ARF-OCE) system was proposed to evaluate LVC by measuring the residual [...] Read more.
Despite the rapidly growing popularity of laser vision correction (LVC) in the correction of myopia, its quantitative evaluation has not been thoroughly investigated. In this paper, an acoustic radiation force–optical coherence elastography (ARF-OCE) system was proposed to evaluate LVC by measuring the residual stromal bed (RSB) elasticity, because it is directly relevant to the RSB thickness that is critical to maintaining normal corneal function. As expected, the Young’s modulus of the RSB was calculated, then its relationship with the RSB thickness was determined. More significantly, a specific thickness was revealed in which the Young’s modulus changed dramatically, which may imply that there is a high risk of complication caused by over-cutting of the cornea. To the best of our knowledge, this is the first ARF-OCE imaging of the RSB, which may help to determine the safe RSB thickness and thus may help us to quantitatively assess LVC surgery. Full article
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography in the Context of Other Biophotonics Techniques)
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21 pages, 2749 KiB  
Article
Compression Optical Coherence Elastography for Assessing Elasticity of the Vaginal Wall under Prolapse after Neodymium Laser Treatment
by Ekaterina Gubarkova, Arseniy Potapov, Darya Krupinova, Ksenia Shatilova, Maria Karabut, Andrey Khlopkov, Maria Loginova, Aleksander Sovetsky, Vladimir Zaitsev, Stefka Radenska-Lopovok, Natalia Gladkova, Gennady Grechkanev and Marina Sirotkina
Photonics 2023, 10(1), 6; https://doi.org/10.3390/photonics10010006 - 22 Dec 2022
Cited by 4 | Viewed by 1940
Abstract
Early stages of pelvic organ prolapses are mainly associated with the pelvic floor disfunction as a result of elasticity changes in the connective tissues including the vaginal wall. In this study, for the first time we used a compression optical coherence elastography (C-OCE) [...] Read more.
Early stages of pelvic organ prolapses are mainly associated with the pelvic floor disfunction as a result of elasticity changes in the connective tissues including the vaginal wall. In this study, for the first time we used a compression optical coherence elastography (C-OCE) method for assessing elasticity of the vaginal wall under prolapse conditions after intravaginal neodymium (Nd:YAG) laser treatment. C-OCE was used for a comparative ex vivo study of vaginal wall average values of stiffness (elastic Young’s modulus) in patients with age norm (n = 6), stage I–II prolapse (n = 5) without treatment and stage I–II prolapse post 1–2 months Nd:YAG laser treatment (n = 10). To verify the C-OCE data, the structural features of the submucosal connective tissue were identified morphometrically by Van Gieson staining using quantitative textural analysis of the state of collagen bundles. The results of a comparative evaluation of C-OCE and histological images demonstrate a statistically significant tissue stiffness decrease in vaginal wall prolapse compared to the age norm (73.5 ± 18.9 kPa vs. 233.5 ± 48.3 kPa; p < 0.05). This agrees with the histologically revealed increase in the space between the bundles of collagen fibers, which leads to a decrease in the uniformity of their arrangement. After Nd:YAG laser treatment, we observed statistically significant connective tissue stiffness increase compared to vaginal wall prolapse without treatment (152.1 ± 19.2 kPa vs. 73.5 ± 18.9 kPa; p < 0.05), which was associated with an increase in the local thickness of the collagen bundles, a change in their orientation, and an increase in the uniformity of their arrangement. The obtained results indicate that the C-OCE can be a robust method for detecting the early stages of vaginal wall prolapse and assessing the elastic modulus increase in the vaginal wall after laser treatment. Full article
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography in the Context of Other Biophotonics Techniques)
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