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Separations
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Advances in Chemical Fingerprint Assessment and Analytical Isolation of Natural...
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Advances in Chemical Fingerprint Assessment and Analytical Isolation of Natural Products and Pharmaceuticals

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 1298

Special Issue Editor

Dr. Arianna Granese

E-Mail Website
Guest Editor
Department of Chemistry and Technologies of Drug, Sapienza University of Rome, piazzale A. Moro 5, 00185 Rome, Italy
Interests: analytical techniques; chemical fingerprints; secondary metabolites; natural products

Special Issue Information

Dear Colleagues,

Natural Products and Pharmaceuticals are a rich resource of potential therapeutics, and they have broad, synergistic actions on physiological systems and a relatively lower incidence of adverse events. Moreover, they have been used as natural remedies to prevent and cure diseases for a long time. Fingerprint analysis has emerged as a very useful technique to assess the quality of natural products by evaluating the whole chemical profile and extracting a pattern to assess the individual material or formulation. HPLC fingerprinting could be used for the comprehensive evaluation and quality assessment of Natural Products and Pharmaceuticals, providing a theoretical basis for future development and utilization. Quality control necessitates the separation and quantification of molecules and the use of advanced techniques for the precise characterization of ingredients. These techniques can also be improved and updated to reduce the costs and minimize sample preparation and the consumption of solvents. Chemical fingerprinting could be applied also for the differentiation of other herbal preparations to control them. The aim of this Special Issue is to investigate the analytical and fingerprinting methods (also hyphenated) to find information and similarities/differences based on certain characteristics. Lastly, knowledge about the chemical structure and amount of impurities and by-products is also important for toxicity and regulatory purposes.

Dr. Arianna Granese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality control
  • contaminants and secondary metabolites
  • chemical fingerprints
  • analytical techniques
  • regulatory guidelines
  • bioactive compounds in natural products

Published Papers (2 papers)

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Research

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14 pages, 840 KiB  
Article
Simultaneous LC-MS/MS Method for the Quantitation of Probenecid, Albendazole, and Its Metabolites in Human Plasma and Dried Blood Spots
by Mamunur Rashid, Yashpal S. Chhonker, Sandeep K. Singh and Daryl J. Murry
Separations 2024, 11(7), 197; https://doi.org/10.3390/separations11070197 - 25 Jun 2024
Viewed by 647
Abstract
Millions of individuals throughout the world suffer from lymphatic filariasis (LF), which is a morbid disease caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori. These infections belong to tissue-invading nematodes and are one of the major neglected tropical diseases [...] Read more.
Millions of individuals throughout the world suffer from lymphatic filariasis (LF), which is a morbid disease caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori. These infections belong to tissue-invading nematodes and are one of the major neglected tropical diseases that often result in permanent and enduring disability among individuals in endemic regions. Due to combination therapy, LF eradication has drastically decreased infections globally. The development of blood micro-sampling techniques allowing precise quantitation of drugs in blood would facilitate pharmacokinetic (PK) studies in remote populations. Therefore, an LC-MS/MS bioanalytical method was utilized to analyze albendazole (ABZ), albendazole sulfone (ABZ-ON), albendazole sulfoxide (ABZ-OX), and probenecid (PR) in plasma and dried blood spots. Solid-phase extraction was utilized to extract the analyte from both plasma and blood-spiked DBS. Analytes of interest were eluted with a gradient mobile system using 0.05% formic acid in water (A) and 0.05% formic acid in methanol (B) and separated using a reversed-phase Acquity ®BEH C18 UPLC column (100 × 2.1 mm, 1.7 µm). Precision and accuracy at each QC level were within the acceptable limit, i.e., ±15% for all analytes in both the matrices. Tests for stability under laboratory and storage conditions indicated that no notable changes were observed for plasma and DBS. The LC-MS/MS method demonstrated its capability to consistently identify all target analytes (ABZ, ABZ-ON, ABZ-OX, and PR) at low concentrations, even at the small specimen volumes obtained from DBS cards. This confirms the efficacy and durability of DBS cards as a micro-sampling technique. Moreover, it enhances collection efforts for therapeutic drug monitoring in remote locations for patients infected with lymphatic filariasis. Full article
(This article belongs to the Special Issue Advances in Chemical Fingerprint Assessment and Analytical Isolation of Natural Products and Pharmaceuticals)

Review

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30 pages, 2012 KiB  
Review
Puerariae lobatae Radix: Progress in Extraction, Separation Methods and Pharmacological Activities Research
by Erjian Gao, Wei Wang, Yuanyuan Huang, Zhijie Luo, Bangzheng Chen, Siqiu **ao and Dewen Li
Separations 2024, 11(7), 195; https://doi.org/10.3390/separations11070195 - 24 Jun 2024
Viewed by 417
Abstract
Kudzu root (Puerariae lobatae Radix) is the tuberous root of Pueraria lobata, family Leguminosae. Kudzu root contains a variety of beneficial active ingredients such as puerarin, daidzin, daidzein, genistenin, 3′-hydroxy puerarin, β-sitosterol, stigmasterol, arachidic acid, and so on. Modern medical research [...] Read more.
Kudzu root (Puerariae lobatae Radix) is the tuberous root of Pueraria lobata, family Leguminosae. Kudzu root contains a variety of beneficial active ingredients such as puerarin, daidzin, daidzein, genistenin, 3′-hydroxy puerarin, β-sitosterol, stigmasterol, arachidic acid, and so on. Modern medical research shows that active ingredients in kudzu root are widely used clinically as raw materials for the treatment of hyperglycemia, non-alcoholic fatty liver disease, myocardial infarction, alcohol addiction, oxidative stress, inflammatory response, and retinal blockage due to their various pharmacological effects such as improving cardiovascular circulation, lowering blood lipids, lowering blood pressure, lowering blood sugar, being antipyretic, being estrogen-like, and relieving alcohol. China has rich resources of kudzu root, and active ingredients are usually extracted before it is made into a preparation, so whether the extraction and separation process is reasonable will directly affect the ease of preparation and the efficacy of the treatment. This paper reviews the process methods for the extraction and separation of active ingredients in kudzu root and its common pharmacological activities. The aim is to provide some references for readers to compare the advantages and disadvantages of various extraction and separation methods as well as understand the active ingredients and pharmacological activities of kudzu root. Full article
(This article belongs to the Special Issue Advances in Chemical Fingerprint Assessment and Analytical Isolation of Natural Products and Pharmaceuticals)
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