Enantioanalysis of Biomedical Compounds and Asymmetric Synthesis in Pharmaceutical Chemistry

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 933

Special Issue Editors


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Guest Editor
Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest, Romania
Interests: electrochemistry; electrochemical sensors; stochastic sensing; chirality; enantiomers

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Guest Editor
Head of Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, 300569 Timișoara, Romania
Interests: electrochemical sensors; chemistry; graphene; biomarkers; gastrointestinal cancer
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Special Issue Information

Dear Colleagues,

Chirality became a very important issue when it was discovered that enantiomers of the same chiral molecule behave differently when used as pharmaceutical compounds or when they proved to be biomarkers for different diseases. Therefore, it was an urgent need for the pharmaceutical industry to develop asymmetric synthesis for almost all chiral drugs, and to verify the pathways of enantiomers in the body. Biomedical enantioanalysis came also with a high challenge and request of high sensitivity, selectivity and enantioselectivity in order to obtain the correct diagnostic. For both pharmaceutical and biomedical analysis there is a continuous challenge in develo** new tools, and highly reliable methods of enantioanalysis.

Please note that all submitted papers must be within the general scope of the Symmetry journal.

Therefore, we welcome papers (original and review articles) to this Special Issue that are dedicated to both asymmetric synthesis and the development of new tools for the enantioanalysis of pharmaceutical compounds and for biomedical enantioanalysis.

Dr. Ruxandra Maria Ilie-Mihai
Prof. Dr. Raluca-Ioana Stefan-van Staden
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

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Published Papers (1 paper)

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Research

11 pages, 1450 KiB  
Article
2D Enantioselective Disposable Stochastic Sensor for Fast Real-Time Enantioanalysis of Glutamine in Biological Samples
by Raluca-Ioana Stefan-van Staden, Mihaela Iuliana Bogea, Ruxandra-Maria Ilie-Mihai, Damaris-Cristina Gheorghe and Marius Badulescu
Symmetry 2023, 15(5), 958; https://doi.org/10.3390/sym15050958 - 22 Apr 2023
Cited by 3 | Viewed by 1225
Abstract
As protein is both a structural component and a metabolic intermediary, amino acids play a crucial function in the body. When it comes to proteins, only the L-configuration of chiral amino acids is found. At the molecular level, symmetry is disrupted; however, the [...] Read more.
As protein is both a structural component and a metabolic intermediary, amino acids play a crucial function in the body. When it comes to proteins, only the L-configuration of chiral amino acids is found. At the molecular level, symmetry is disrupted; however, the scientific basis for this symmetry breaking is not yet known. Enantioanalysis of chiral compounds such as amino acids plays a very important role in the correct diagnosis of illnesses, such as cancer. The enantiomers of glutamine—a chiral amino acid—were investigated in biological samples using a disposable stochastic sensor. The disposable stochastic sensor based on immobilization of maltodextrin (DE 4.0–7.0) on the surface of a disposable sensor based on graphene decorated with Ag was designed, characterized, and validated for screening tests of whole blood and tissue samples. The stochastic sensor was designed using cold plasma deposition of graphene decorated with Ag on plastic material. The sensor was enantioselective, being able to discriminate between the enantiomers of glutamine. High sensitivities were recorded for both enantiomers, while the limits of determination were 100 fmol L−1 for L-glutamine and 1 fmol L−1 for D-glutamine. High recoveries were determined for the assay of one enantiomer in the presence of the other, despite the ratio between the two enantiomers. Full article
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