Oxidative Stress and Antioxidants in Carcinogenesis: A Multifaceted Approach

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 October 2024 | Viewed by 640

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Guest Editor
Institute of Bioscience, São Paulo State University, Botucatu, SP, Brazil
Interests: metabolic disorders; liver cancer; alternative treatments; energetic metabolism
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Special Issue Information

Dear Colleagues,

We are in the process of preparing a new Special Issue entitled "Oxidative Stress and Antioxidants in Carcinogenesis: A Multifaceted Approach", and I would like to extend a cordial invitation to all those engaged in this dynamic field, spanning from bench research to clinical trials. Our aim is to publish well-designed studies that characterize, elucidate and corroborate the role of oxidative stress in carcinogenesis. We are also interested in papers that explore the potential application of alternative therapies that utilize antioxidants. The role of free radicals in the development of some types of tumors is well-established. Paradoxically, increased reactive species can be a valuable tool in combating tumor proliferation. Given the abundance of natural antioxidants found in nature, this area of research not only holds promise, but is also of paramount relevance and immediacy. In today's era, the various well-established "omics" release a large amount of experimental data. Studies using bioinformatics approaches are therefore also welcome, as well as articles addressing the interplay between oxidative stress, antioxidants, and cancer pathogenesis.

Prof. Dr. Fábio Rodrigues Ferreira Seiva
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • tumor biology
  • bioactive molecules
  • natural compounds
  • free radicals
  • alternative treatments

Published Papers (1 paper)

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Review

17 pages, 1188 KiB  
Review
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells
by Juan De los Santos-Jiménez, José A. Campos-Sandoval, Francisco J. Alonso, Javier Márquez and José M. Matés
Antioxidants 2024, 13(6), 745; https://doi.org/10.3390/antiox13060745 - 20 Jun 2024
Viewed by 469
Abstract
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named GLS and GLS2, which differ considerably in their expression [...] Read more.
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named GLS and GLS2, which differ considerably in their expression patterns and can even perform opposing roles in cancer. GLS correlates with tumor growth and proliferation, while GLS2 can function as a context-dependent tumor suppressor. However, both isoenzymes have been described as essential molecules handling oxidant stress because of their involvement in glutathione production. We reviewed the literature to highlight the critical roles of GLS and GLS2 in restraining ROS and regulating both cellular signaling and metabolic stress due to their function as indirect antioxidant enzymes, as well as by modulating both reductive carboxylation and ferroptosis. Blocking GA activity appears to be a potential strategy in the dual activation of ferroptosis and inhibition of cancer cell growth in a ROS-mediated mechanism. Full article
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