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Antioxidants
Special Issues
Antioxidant Compounds from Marine Organisms
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Antioxidant Compounds from Marine Organisms

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 5340

Special Issue Editors

Dr. Dimitrios Stagos

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Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Interests: antioxidant activity of plant extracts, plant polyphenols and other natural products; physiological adaptive mechanisms of human organism to oxidative stress conditions; chemopreventive (anticarcinogenic) activity of plant extracts, plant polyphenols and other natural products; anti-angiogenic activity of chemical compounds (natural or synthetic); biochemical and physiological role of human aldehyde dehydrogenases
Special Issues, Collections and Topics in MDPI journals
Dr. Varvara Trachana

E-Mail Website
Guest Editor
Department of Medicine, University of Thessaly, Larissa, Greece
Interests: anti-aging; oxidative stress; antioxidants; DNA damage
Special Issues, Collections and Topics in MDPI journals
Dr. Nikolaos Goutzourelas

E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Interests: antioxidants; chemoprevention; anticancer; oxidative stress; plant extracts; plant polyphenols
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oceans cover > 70% of the Earth’s surface and are a habitat for an immense variety of marine organisms. These species produce a high number of natural products, many of which exhibit important bioactivities compared to or even higher than those of terrestrial organisms. Moreover, marine organisms are often exposed to environmental stresses and extreme conditions that force them to produce protective mechanisms such as secondary metabolites and macromolecules possessing antioxidant activity. Thus, various antioxidant compounds, such as peptides, phenols, polysaccharides, carotenoids, terpenoids, polyketides, alkaloids, sterols, pigments, carbohydrates and polyunsaturated fatty acids, have been identified in a variety of marine organisms (e.g., seaweeds, microalgae, sponges, ascidians, bacteria, fungi and bryozoan). However, marine biota constitute an underexplored rich source of high-value molecules with beneficial effects for human health, and so there has been great research interest in discovering new bioactive compounds. In this Special Issue, we invite researchers to submit their latest research findings or original review articles which will bring together current research and highlight the newest data and critical discussions on the following subjects: the isolation and potency assessment of marine organisms’ antioxidant compounds (i.e., individual substances or chemical mixtures), the production of synthetic analogues based on antioxidant substances of marine origin, the role of marine organisms’ compounds in preventing oxidative stress-induced diseases and the investigation of the molecular mechanisms accounting for marine compounds’ antioxidant activity.

Dr. Dimitrios Stagos
Dr. Varvara Trachana
Dr. Nikolaos Goutzourelas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • marine organisms
  • natural compounds
  • oxidative stress
  • chemoprevention
  • chemical synthesis
  • extraction
 

Published Papers (3 papers)

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Research

16 pages, 3135 KiB  
Article
A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease
by Hung-Tsung Wu, Chin-Shiang Tsai, Ting-Hsing Chao, Horng-Yih Ou and Liang-Miin Tsai
Antioxidants 2024, 13(6), 746; https://doi.org/10.3390/antiox13060746 - 20 Jun 2024
Viewed by 704
Abstract
The prevalence of non-alcoholic fatty liver disease (NAFLD) has dramatically increased in recent years, and it is highly associated with metabolic diseases, as well as the development of hepatocellular carcinoma. However, effective therapeutic strategies for the treatment of NAFLD are still scarce. Although [...] Read more.
The prevalence of non-alcoholic fatty liver disease (NAFLD) has dramatically increased in recent years, and it is highly associated with metabolic diseases, as well as the development of hepatocellular carcinoma. However, effective therapeutic strategies for the treatment of NAFLD are still scarce. Although hydrogen-rich water shows beneficial effects for hepatic steatosis, the inconvenience limits the application of this antioxidant. In light of this, hydrogen-rich coral calcium (HRCC) was developed due to its convenience and quantifiable characteristics. However, the effects of HRCC on NAFLD are still unknown. In the present study, we found that HRCC treatment improved methionine-and-choline-deficient diet (MCD)-induced hepatic steatosis, increased aspartate aminotransferase and alanine aminotransferase levels, and elevated hepatic inflammatory factor expressions in mice. In addition to the increased expressions of antioxidative enzymes, we found that HRCC increased the expressions of bile acid biosynthesis-related genes, including Cyp8b1 and Cyp27a1. Increased hepatic bile acid contents, such as muricholic acids, 23 nor-deoxycholic acid, glycoursodeoxycholic acid, and cholic acids, were also confirmed in MCD mice treated with HRCC. Since the biogenesis of bile acids is associated with the constitution of gut microbiome, the alterations in gut microbiome by HRCC were evaluated. We found that HRCC significantly changed the constitution of gut microbiome in MCD mice and increased the contents of Anaerobacterium, Acutalibacter, Anaerosacchariphilus, and Corynebacterium. Taken together, HRCC improved MCD-induced NAFLD through anti-inflammatory mechanisms and by increasing antioxidative activities. Additionally, HRCC might alter gut microbiome to change hepatic bile acid contents, exerting beneficial effects for the treatment of NAFLD. Full article
(This article belongs to the Special Issue Antioxidant Compounds from Marine Organisms)
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13 pages, 2603 KiB  
Article
A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products
by Luca Melotti, Andrea Venerando, Giulia Zivelonghi, Anna Carolo, Stefania Marzorati, Giordana Martinelli, Michela Sugni, Lisa Maccatrozzo and Marco Patruno
Antioxidants 2023, 12(9), 1730; https://doi.org/10.3390/antiox12091730 - 7 Sep 2023
Cited by 1 | Viewed by 1435
Abstract
Co** with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (Paracentrotus lividus) food waste, it is possible to obtain both [...] Read more.
Co** with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (Paracentrotus lividus) food waste, it is possible to obtain both a high biocompatible collagen to produce novel skin substitutes and potent antioxidant pigments, namely polyhydroxynapthoquinones (PHNQs). Herein, we have analyzed the biological activities of the PHNQs extract, composed of Spinochrome A and B, on human skin fibroblast cells to explore their future applicability in the treatment of non-healing skin wounds with the objective of overcoming the excessive oxidative stress that hinders wound tissue regeneration. Our results clearly demonstrate that the antioxidant activity of PHNQs is not restricted to their ability to scavenge reactive oxygen species; rather, it can be traced back to an upregulating effect on the expression of superoxide dismutase 1, one of the major components of the endogenous antioxidant enzymes defense system. In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications. Full article
(This article belongs to the Special Issue Antioxidant Compounds from Marine Organisms)
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16 pages, 1279 KiB  
Article
Edible Seaweeds Extracts: Characterization and Functional Properties for Health Conditions
by Mariana Coelho, Ana Patrícia Duarte, Sofia Pinto, Hugo M. Botelho, Catarina Pinto Reis, Maria Luísa Serralheiro and Rita Pacheco
Antioxidants 2023, 12(3), 684; https://doi.org/10.3390/antiox12030684 - 10 Mar 2023
Cited by 5 | Viewed by 2585
Abstract
Seaweeds are popular foods due to claimed beneficial health effects, but for many there is a lack of scientific evidence. In this study, extracts of the edible seaweeds Aramé, Nori, and Fucus are compared. Our approach intends to clarify similarities and differences in [...] Read more.
Seaweeds are popular foods due to claimed beneficial health effects, but for many there is a lack of scientific evidence. In this study, extracts of the edible seaweeds Aramé, Nori, and Fucus are compared. Our approach intends to clarify similarities and differences in the health properties of these seaweeds, thus contributing to target potential applications for each. Additionally, although Aramé and Fucus seaweeds are highly explored, information on Nori composition and bioactivities is scarce. The aqueous extracts of the seaweeds were obtained by decoction, then fractionated and characterized according to their composition and biological activity. It was recognized that fractioning the extracts led to bioactivity reduction, suggesting a loss of bioactive compounds synergies. The Aramé extract showed the highest antioxidant activity and Nori exhibited the highest potential for acetylcholinesterase inhibition. The identification of the bioactive compounds in the extracts allowed to see that these contained a mixture of phloroglucinol polymers, and it was suggested that Nori’s effect on acetylcholinesterase inhibition may be associated with a smaller sized phlorotannins capable of entering the enzyme active site. Overall, these results suggest a promising potential for the use of these seaweed extracts, mainly Aramé and Nori, in health improvement and management of diseases, namely those associated to oxidative stress and neurodegeneration. Full article
(This article belongs to the Special Issue Antioxidant Compounds from Marine Organisms)
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