An Integrated Approach on Cerebral Venous Sinus Thrombosis (CVST): 2nd Edition

Dear Colleagues,

Cerebral venous thrombosis (CVT) is an uncommon disorder in the general population. At least one risk factor can be identified in 85% of patients with CVT. Because of the high frequency of thrombophilia among patients with CVT, screening for hypercoagulable conditions should be performed. Two pathophysiological mechanisms contribute to their highly variable clinical presentation (the increase of venular and capillary pressure and decrease of cerebrospinal fluid absorption). Four major syndromes have been described: isolated intracranial hypertension, focal neurological abnormalities, seizures, and encephalopathy. Cavernous sinus thrombosis represents the only CVT that produces a characteristic clinical syndrome. Head computed tomography is the most frequently performed imaging study, but magnetic resonance imaging of the head, combined with magnetic resonance venography, are the most sensitive studies. Acute-phase therapy for CVT focuses on anticoagulation, the management of seizures, increased intracranial pressure, and the prevention of cerebral herniation. The majority of patients have a complete or partial recovery; however, they have an increased incidence of venous thromboembolism. Clinical and imaging follow-ups 3 to 6 months after diagnosis are recommended to assess for recanalization.

This Special Issue of Life (IF=3.253) includes, but is not limited to, the following topics: the anatomy of dural sinuses and encephalic veins; the epidemiology, risk factors, and pathophysiology of CVT; and the clinical presentation, laboratory testing (including thrombophilia testing), and imaging of CVT. The management of CVT represents another important aspect, devoted to acute phase therapy, the management after the acute phase, and the prognosis of patients with CVT.

I am pleased to invite you to submit a manuscript covering experimental and clinical research, as well as systematic reviews and meta-analyses.

Accepted papers will be published continuously in the journal (as soon as accepted), and will be listed together on the Special Issue’s website.

Prof. Dr. Dragos Catalin Jianu
Dr. Jean Claude Sadik
Prof. Dr. Dafin Fior Mureşanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cerebral venous thrombosis
• thrombophilia
• isolated intracranial hypertension
• magnetic resonance imaging of the head
• magnetic resonance venography
• anticoagulation