Journal Description
COVID
COVID
is an international, peer-reviewed, open access journal on the study of coronaviruses, coronavirus-related diseases and global impact, published monthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within ESCI (Web of Science), Scopus, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 17.7 days after submission; acceptance to publication is undertaken in 2.6 days (median values for papers published in this journal in the first half of 2024).
- Recognition of Reviewers: APC discount vouchers, optional signed peer review, and reviewer names published annually in the journal.
- COVID is a companion journal of Viruses.
Latest Articles
Antibiotic Misuse during the COVID-19 Pandemic in Lebanon: A Cross-Sectional Study
COVID 2024, 4(7), 921-929; https://doi.org/10.3390/covid4070064 (registering DOI) - 30 Jun 2024
Abstract
Background: Over the past 100 years, the discovery of antibiotics is regarded as one of the most significant advances in medical research and has saved millions of lives. However, the emergence of antimicrobial-resistant bacteria has significantly reduced the efficacy of antibiotics against infectious
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Background: Over the past 100 years, the discovery of antibiotics is regarded as one of the most significant advances in medical research and has saved millions of lives. However, the emergence of antimicrobial-resistant bacteria has significantly reduced the efficacy of antibiotics against infectious disorders. Antimicrobial resistance is mostly caused by antibiotic misuse for conditions that may be treated with self-care. During the COVID-19 pandemic, antibiotic use has been out of control among the general population. Aim: The objective of this study is to investigate the prevalence of antibiotic misuse during the COVID-19 pandemic in Lebanon. Methods: In January 2024, a descriptive cross-sectional study was conducted amongst students registered at the Islamic University of Lebanon. Individuals who have been infected with COVID-19 at least once were eligible for the study and were selected by a non-random snowball sampling technique. Descriptive and quantitative analyses were performed using SPSS 21. Results: Out of the 478 participants who completed the questionnaire, 40.2% (n = 192) received antibiotics during the COVID-19 infection. A physician’s prescription is mentioned by some participants (51%, n = 98), followed by a pharmacist’s (23.4%, n = 45), self-taken (14.5%, n = 28), and others as family or friends (10.9%, n = 21). Moreover, 59.3% (n = 114) of the respondents respected the antibiotic therapy’s rules, and 40.6% (n = 78) discontinued taking the antibiotic when they felt better. Conclusion: Our results showed that participants were likely to show unsatisfactory compliance and to use non-prescribed antibiotics. Campaigns are urgently needed to promote appropriate antibiotic use.
Full article
Open AccessArticle
Effect of SARS-CoV-2 Infection on Renal and Hepatic Function after NSAID and Paracetamol Therapy
by
Aurélie Pahud de Mortanges, Evangelia Liakoni, Verena Schöning and Felix Hammann
COVID 2024, 4(7), 910-920; https://doi.org/10.3390/covid4070063 - 27 Jun 2024
Abstract
NSAIDs and paracetamol are commonly used as antipyretic treatments, which may impair renal and hepatic function, respectively. Both organ systems are also negatively affected by COVID-19. In two retrospective case–control studies, we investigated whether COVID-19 is a risk factor for the development of
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NSAIDs and paracetamol are commonly used as antipyretic treatments, which may impair renal and hepatic function, respectively. Both organ systems are also negatively affected by COVID-19. In two retrospective case–control studies, we investigated whether COVID-19 is a risk factor for the development of renal or hepatic function impairment after NSAID and paracetamol use, respectively. In the NSAID study, we defined cases as patients with a decrease of ≥15% in the estimated glomerular filtration rate (eGFR). We matched them using a 1:2 ratio with controls who did not show a decrease in the eGFR. For the paracetamol study, we matched patients with ALT or ALP ≥ 3x, the upper limits of normal, using a 1:3 ratio with controls whose liver enzymes did not increase. In both studies, we selected demographic data, comorbidities, drug doses, and laboratory values as predictors in addition to SARS-CoV-2 test status. We applied different machine learning models to predict renal and hepatic function impairment. From the cohort of 12,263 unique adult inpatients, we found 288 cases of renal function impairment, which were matched with 576 controls, and 213 cases of liver function impairment, which were matched with 639 controls. In both case–control studies, testing positive for SARS-CoV-2 was not an independent risk factor for the studied adverse drug effects.
Full article
Open AccessSystematic Review
“I Am Actually Scared of Everyone”: Older Adults’ Experiences of Social Isolation during COVID-19: A Qualitative Systematic Review
by
Oladapo Akinlotan and Aishatu Jalo
COVID 2024, 4(7), 896-909; https://doi.org/10.3390/covid4070062 - 27 Jun 2024
Abstract
The emergence of the coronavirus COVID-19 in December 2019 in Wuhan, China, affected all facets of people’s lives worldwide. As a result of the severity of the pandemic, governments worldwide adopted several policies and containment measures, such as social isolation, especially for vulnerable
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The emergence of the coronavirus COVID-19 in December 2019 in Wuhan, China, affected all facets of people’s lives worldwide. As a result of the severity of the pandemic, governments worldwide adopted several policies and containment measures, such as social isolation, especially for vulnerable populations, including older adults. This study aimed to explore these older adults’ experiences of social isolation during COVID-19. A systematic review method based on the PRISMA protocol was used, and five databases (EMBASE, PsycINFO, PsycEXTRA, CINAHL, and Medline) were comprehensively searched. Studies were limited to those published between 2020 and 2023. Thirteen qualitative studies met the inclusion criteria and were analysed thematically. A thematic analysis identified the following five major themes: intense feeling of loneliness due to social isolation; use of social media as a co** mechanism during social isolation; anxiety during social isolation; fear during social isolation; and financial security during social isolation. This review provides useful information on how to mitigate the effects of social isolation on the elderly population during future public health crises.
Full article
Open AccessCase Report
Ocular Ischemic Events and Vision Loss Associated with COVID-19 Acute Hypoxic Respiratory Failure
by
K’Mani K. Blyden, Tolulope Fashina, Casey Randleman, William Pearce, Jill Wells, Steven Yeh and Jessica G. Shantha
COVID 2024, 4(7), 890-895; https://doi.org/10.3390/covid4070061 - 27 Jun 2024
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Coronavirus disease 2019 (COVID-19) is associated with increased risk of microvascular complications; however, reports of ophthalmic manifestations associated with retinal vascular occlusion associated with COVID-19 are limited. In this report, we describe two middle-aged female patients who were admitted for acute hypoxic respiratory
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Coronavirus disease 2019 (COVID-19) is associated with increased risk of microvascular complications; however, reports of ophthalmic manifestations associated with retinal vascular occlusion associated with COVID-19 are limited. In this report, we describe two middle-aged female patients who were admitted for acute hypoxic respiratory failure secondary to COVID-19-induced pneumonia. Following prolonged intensive care unit admission requiring mechanical ventilation and critical care interventions, both patients reported substantially reduced vision upon regaining consciousness. Dilated funduscopic exam showed multiple blot hemorrhages in all quadrants of the posterior pole, bilateral retinal hemorrhage, macular edema, and retinal vascular tortuosity. Both patients were diagnosed with retinal ischemic events owing to bilateral ophthalmic artery occlusion in the first patient, and bilateral central retinal vein occlusion (CRVO) in the second individual. While uncommon, retinal microvascular complications associated with COVID-19 leading to vision loss require prompt evaluation and referral given their potential long-term impact following acute illness.
Full article
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Open AccessArticle
A Paradigm Shift: The Reclassification of SARS-CoV-2 and Longitudinal Immune Responses in Japanese Healthcare Workers
by
Tokuhiro Chano, Hiroko Kita, Tomoko Yamashita, Hirokazu Fujimura and Toshiyuki Ikemoto
COVID 2024, 4(7), 884-889; https://doi.org/10.3390/covid4070060 - 26 Jun 2024
Abstract
Under the aegis of the National Infectious Diseases Act, the virus transitioned from a category 2 menace to category 5, analogous to seasonal influenza. For this classification to be appropriate, a comprehensive assessment of the immune status of the Japanese population must be
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Under the aegis of the National Infectious Diseases Act, the virus transitioned from a category 2 menace to category 5, analogous to seasonal influenza. For this classification to be appropriate, a comprehensive assessment of the immune status of the Japanese population must be conducted to ensure adequacy. The current study has investigated the protracted immune responses of healthcare workers (HCWs) to SARS-CoV-2 in Japan. One year subsequent to the systematically implemented SARS-CoV-2 vaccination campaign among HCWs, humoral and cellular immune responses were sustained at levels as high as or higher than those immediately following the third booster vaccination. Persisting immunity has highlighted the resilience and lasting memory exhibited in HCW defense against the virus, suggesting that the classification of SARS-CoV-2 infection as a category 5 in Japan has appeared judicious.
Full article
Open AccessArticle
Emotions, Risk Perception and Preventive Behavior during the COVID-19 Pandemic: The Mediating Role of Media Use
by
Shosh Shahrabani and Sharon Garyn-Tal
COVID 2024, 4(7), 872-883; https://doi.org/10.3390/covid4070059 - 26 Jun 2024
Abstract
As a result of the COVID-19 pandemic, media consumption has begun playing a more significant role in sha** public perceptions and well-being. The current study examines the effects of risk perception, economic situation, and negative emotions during the COVID-19 pandemic on preventive behaviors,
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As a result of the COVID-19 pandemic, media consumption has begun playing a more significant role in sha** public perceptions and well-being. The current study examines the effects of risk perception, economic situation, and negative emotions during the COVID-19 pandemic on preventive behaviors, while focusing on the mediating role of media exposure levels. An online survey was conducted during the 2020 outbreak of COVID-19 in Israel. SEM analysis results show that during the pandemic, media exposure increased with negative emotions levels, increased with higher exposure to the pandemic and increased as the economic impact of the pandemic increased. In addition, preventive behavior increased with media exposure. Moreover, the media exposure variable was found to mediate the effect of negative emotions and of the perceived risk of being infected with coronavirus on preventive behavior. Implications for government policy are discussed.
Full article
Open AccessArticle
Emotional Regulation, Adult Attachment Orientations, and Risk of COVID-19 Infection: Virtual Reality Simulation
by
Ricardo J. Pinto, Sara Albuquerque, Maria Vieira de Castro, Pedro Gamito, Inês Jongenelen and Alytia Levendosky
COVID 2024, 4(7), 859-871; https://doi.org/10.3390/covid4070058 - 26 Jun 2024
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(1) Background: To mitigate COVID-19 transmission, global public health interventions were swiftly implemented. However, a comprehensive understanding of individual variations in adhering to these recommendations remains elusive. Addressing this gap is crucial for effectively managing future epidemic and pandemic scenarios. This study aims
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(1) Background: To mitigate COVID-19 transmission, global public health interventions were swiftly implemented. However, a comprehensive understanding of individual variations in adhering to these recommendations remains elusive. Addressing this gap is crucial for effectively managing future epidemic and pandemic scenarios. This study aims to explore individual differences in attachment, emotion regulation, and risk for COVID-19 infection using virtual reality (VR). (2) Methods: The sample included 73 (88%) university students and 10 (12%) university staff. Participants completed questionnaires on sociodemographic information, the Difficulties in Emotion Regulation Scale, the Experiences in Close Relationships—Relationship Structures Questionnaire, and the fear of COVID-19 Scale. Additionally, each participant engaged in five daily situations using a VR simulator to assess the risk of COVID-19 infection. (3) Results: Our study revealed that high levels of attachment anxiety, difficulties controlling impulsive behaviors, and limited access to emotion regulation strategies were strong predictors of elevated risk of COVID-19 infection. Conversely, high levels of fear of COVID-19 and attachment avoidance were associated with lower risk of COVID-19 infection. (4) Conclusions: We discuss the importance of policymakers and health professionals being aware of some psychological characteristics that make it difficult for some individuals to adhere to public health measures involving social distancing.
Full article
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Open AccessArticle
A One-Year Follow-Up Cohort Study of Ambulatory Patients with SARS-CoV-2 Infection: The Landscape in Mexico
by
Andreu Comas-García, Berenice Hernández-Castro, Ricardo Sebastián Hernández-Salazar, Marlen Vitales-Noyola, Diana Lorena Alvarado-Hernández, Pedro Gerardo Hernández-Sánchez, Ana Elena Sánchez-Rodríguez, Jesús Salvador González-López, Jaime Enrique Méndez-Ramírez, Roberto González-Amaro and Sofía Bernal-Silva
COVID 2024, 4(7), 848-858; https://doi.org/10.3390/covid4070057 - 21 Jun 2024
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Background and Objectives: SARS-CoV-2 is the pathogen that causes COVID-19 disease. Although the rate of COVID-19 reinfection is significant, the possible factors associated with this condition remain to be fully elucidated. The aim of the study was to identify clinical and serological
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Background and Objectives: SARS-CoV-2 is the pathogen that causes COVID-19 disease. Although the rate of COVID-19 reinfection is significant, the possible factors associated with this condition remain to be fully elucidated. The aim of the study was to identify clinical and serological factors associated with SARS-CoV-2 reinfection. Materials and Methods: We followed up on 120 patients with mild COVID-19 for one year. Various clinical data were collected, and serum levels of IgG anti-SARS-CoV-2 Spike antibodies were tested on days 21, 60, 90, and 180. The diagnosis of COVID-19 was based on symptomatology and the detection of viral RNA in nasal swabs using real-time PCR. Results: We observed eleven episodes of reinfection. Although no clinical or demographic characteristics were associated with reinfection, significantly higher levels of anti-Spike antibodies and a seropositive status at day 90 were significantly associated with the absence of reinfection. Moreover, the symptoms during the COVID-19 episode associated with seropositivity at day 90 were mainly headache, sneezing, anosmia, and runny nose. Conclusions: SARS-CoV-2 reinfection is not associated with the clinical or demographic characteristics of COVID-19 patients. Furthermore, our findings suggest that the presence and levels of IgG anti-Spike antibodies at day 90 of infection play a protective role against reinfection. Serological immunity at day 90 influences the response to vaccination.
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Open AccessArticle
Screening of Omicron Virus Strain by Quantifying the Spike Protein Content
by
Zhenyu He, Hengzhen Chang, Yichuan Wang, Siman **e, Yingwei Liu, Yuxiu Zhao, Na Li and Yuntao Zhang
COVID 2024, 4(6), 838-847; https://doi.org/10.3390/covid4060056 - 20 Jun 2024
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In the development of an inactivated virus vaccine, the isolation of a single virus strain plays a key role in determining potency. The conventional methods of quantification of virus number are mainly based on virus titers, which are subjective and time-consuming, especially in
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In the development of an inactivated virus vaccine, the isolation of a single virus strain plays a key role in determining potency. The conventional methods of quantification of virus number are mainly based on virus titers, which are subjective and time-consuming, especially in the early stage of virus isolation, in which the titer difference is weak. Previous reports have shown a high correlation between the spike protein and the potency of COVID-19 vaccines. In this paper, we report a novel, fast, and convenient method of screening an Omicron virus strain by quantifying the spike protein content, where the isolated strain shows high affinity to Omicron-specific antibodies and a high titer, and it can induce high levels of neutralization antibodies.
Full article
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Open AccessArticle
Predicting Transmissibility-Increasing Coronavirus (SARS-CoV-2) Mutations
by
Ege Çalışkan, Murat Işık, Cansu İlke Kuru and Somenath Chakraborty
COVID 2024, 4(6), 825-837; https://doi.org/10.3390/covid4060055 - 19 Jun 2024
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Advantageous variants of the SARS-CoV-2 virus have arisen through mutations, particularly on a single amino acid basis. These point mutations can cause changes in the structure of SARS-CoV-2 and affect the efficiency of interaction with the ACE2 protein. N501Y and E484K mutations affecting
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Advantageous variants of the SARS-CoV-2 virus have arisen through mutations, particularly on a single amino acid basis. These point mutations can cause changes in the structure of SARS-CoV-2 and affect the efficiency of interaction with the ACE2 protein. N501Y and E484K mutations affecting binding by ACE2 have been widely observed. This study aimed to predict SARS-CoV-2 mutations that could be as effective as N501Y and E484K and pose a danger due to their high contagiousness. Experimental data on SARS-CoV-2 and ACE2 binding and stability were associated with different amino acid properties and integrated into machine learning and computational biology techniques. As a result of the analyses made in algorithms, N501M, Q414A, N354K, Q498H and N460K have been predicted to be likely to have a dangerous effect. The N501W mutations are most likely to have dangerous effects on the spread of the coronavirus. We suggest that attention should be paid to the position 501 mutation since this position is repeated in the lists of mutations that the algorithm detected as dangerous. G446, G447, Y505, T500, Q493, Y473, and G476 were determined as the positions where dangerous variants could be seen as a result of the analyses of the multiple interaction data created with the ACE2 and RBD interaction data. The 13 dangerous positions and mutations have been detected to accurately describe the position of the mutations caused by the Omicron variant and were among the known dangerous mutations similar to those occurring at Q498, G446, Y505 and Q493 positions.
Full article
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Open AccessArticle
A Hungarian Centrum Hospital’s COVID-19 Response Strategy in Light of International Management Experiences
by
László Schandl, Barnabás Kiss, Zoltán Lengyel, János Tibor Kis and Gábor Winkler
COVID 2024, 4(6), 815-824; https://doi.org/10.3390/covid4060054 - 17 Jun 2024
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The COVID-19 pandemic has placed enormous pressure on healthcare systems. In the first line of the “war” against the virus, hospitals tried to maintain their general operations, while supplementing their services with COVID-19 patient care. To tackle the new difficulties, hospitals had to
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The COVID-19 pandemic has placed enormous pressure on healthcare systems. In the first line of the “war” against the virus, hospitals tried to maintain their general operations, while supplementing their services with COVID-19 patient care. To tackle the new difficulties, hospitals had to develop strategic response plans, and were in need of finding the most effective management structure for their institution. The focus of this paper is the aforementioned management structures. After overviewing the international literature, we identified three different approaches and we named them the Horizontal, Vertical, and Intermedier Approach. The separation is based on the following features: decision making, information distribution, command forwarding, intra-hospital communication channels, hierarchy, and control. After summarizing the international experiences, we introduce a Hungarian centrum hospital’s approach, as the institution was assigned to fulfil COVID-19 centrum hospital duties in the middle of the first wave. The North-Buda Szent János Central hospital was in need of restructuring their management structure, and the leadership decided to transform it into a hierarchical, vertical structure, operating with centralized decision making and personal control. This control–command system idea came from the hospital’s Internist Head Coordinator Physician, who is the first author of our article, and had serious military medicine experiences (in Afghanistan).
Full article
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Open AccessArticle
Mitigating Social Isolation Following the COVID-19 Pandemic: Remedy Messages Shared by Older People
by
Gail Low, Sofia von Humboldt, Gloria Gutman, Zhiwei Gao, Hunaina Allana, Anila Naz, Donna M. Wilson and Muneerah Vastani
COVID 2024, 4(6), 798-814; https://doi.org/10.3390/covid4060053 - 16 Jun 2024
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At the beginning of July 2022, when public health restrictions were lifted, we deployed a country-wide e-survey about how older people were managing now after COVID-19 pandemic-related anxiety. Our responder sample was stratified by age, sex, and education to approximate the Canadian population.
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At the beginning of July 2022, when public health restrictions were lifted, we deployed a country-wide e-survey about how older people were managing now after COVID-19 pandemic-related anxiety. Our responder sample was stratified by age, sex, and education to approximate the Canadian population. E-survey responders were asked to share open-text messages about what contemporaries could do to live less socially isolated lives at this tenuous turning point following the pandemic as the COVID-19 virus still lingered. Contracting COVID-19 enhanced older Canadians’ risk for being hospitalized and/or mortality risk. Messages were shared by 1189 of our 1327 e-survey responders. Content analysis revealed the following four calls to action: (1) cultivating community; (2) making room for what is good; (3) not letting your guard down; and (4) voicing out challenges. Responders with no chronic illnesses were more likely to endorse making room for what is good. Those with no diploma, degree, or certificate least frequently instructed others to not let their guard down. While COVID-19 is no longer a major public health risk, a worrisome proportion of older people across the globe are still living socially isolated. We encourage health and social care practitioners and older people to share messages identified in this study with more isolated persons.
Full article
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Open AccessArticle
Determining Factors Influencing Filipinos’ Behavioral Protection against COVID: Integrating Extended Protection Motivation Theory, Theory of Planned Behavior, and Ergonomic Appraisal
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Ma. Janice J. Gumasing, Frankern Luis S. Malabuyoc, Ardvin Kester S. Ong and Charmine Sheena Saflor
COVID 2024, 4(6), 771-797; https://doi.org/10.3390/covid4060052 - 13 Jun 2024
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This study examined the perceived protective behavior of Filipinos towards COVID-19. It utilized the extended protection motivation theory (PMT) and theory of planned behavior (TPB) models with the integration of ergonomic appraisal, applying partial least square structural equation modeling (PLS-SEM) to determine the
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This study examined the perceived protective behavior of Filipinos towards COVID-19. It utilized the extended protection motivation theory (PMT) and theory of planned behavior (TPB) models with the integration of ergonomic appraisal, applying partial least square structural equation modeling (PLS-SEM) to determine the factors affecting the protective behavior of Filipinos against COVID-19. A questionnaire was developed and distributed to 3000 Filipino citizens to measure the factors and their relationships. Results showed that understanding COVID-19 significantly influences the Filipinos’ perceived virus severity and vulnerability. In turn, perceived severity, self-efficacy, attitude, and subjective norms were the significant factors that affected the behavioral intention, impacting protective behavior. In addition, cognitive and macro ergonomics have been found to be the factors that influence the protective behavior of Filipinos against COVID-19. Thus, the study’s findings can be used as a framework for develo** pandemic response initiatives that aim to inform and educate Filipinos, especially those who do not have the privilege of accessing information. Lastly, the outcome of this study can be used as a theoretical framework for future researchers who aim to conduct a study in a similar discipline.
Full article
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Open AccessPerspective
Deepening Divides or Inciting Change? Ongoing Impacts of COVID-19 on Teaching and Teacher Education in the United States
by
Noah Borrero
COVID 2024, 4(6), 761-770; https://doi.org/10.3390/covid4060051 - 8 Jun 2024
Abstract
Through the lenses of teaching and teacher education, this article explores the evolving impacts of the COVID-19 pandemic on education. Challenges associated with COVID-19 in schooling, learning, teaching, and teacher education are highlighted to showcase ongoing systemic inadequacies and emerging opportunities for change.
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Through the lenses of teaching and teacher education, this article explores the evolving impacts of the COVID-19 pandemic on education. Challenges associated with COVID-19 in schooling, learning, teaching, and teacher education are highlighted to showcase ongoing systemic inadequacies and emerging opportunities for change. Cultural assets are presented as a theoretical framework for bridging gaps between individualistic and collective approaches to learning. Specific classroom projects that foster cultural assets are connected with a larger educational movement for Ethnic Studies in public education in the United States to provide examples of ways that education can evolve in more equitable ways into the future.
Full article
Open AccessArticle
Psychological Determinants of COVID-19 Vaccination Uptake among Pregnant Women in Kenya: A Comprehensive Model Integrating Health Belief Model Constructs, Anticipated Regret, and Trust in Health Authorities
by
Sylvia Ayieko, Christine Markham, Kimberly Baker and Sarah E. Messiah
COVID 2024, 4(6), 749-760; https://doi.org/10.3390/covid4060050 - 5 Jun 2024
Abstract
Pregnant women, considered at risk of COVID-19 complications because of the immunosuppressive and physiological changes in pregnancy, were initially hesitant to receive COVID-19 vaccination. This study assessed the association between COVID-19 vaccination uptake, psychological determinants (health belief model (HBM) constructs, anticipated regret, trust
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Pregnant women, considered at risk of COVID-19 complications because of the immunosuppressive and physiological changes in pregnancy, were initially hesitant to receive COVID-19 vaccination. This study assessed the association between COVID-19 vaccination uptake, psychological determinants (health belief model (HBM) constructs, anticipated regret, trust in health authorities), and provider recommendation among pregnant women in Kenya. Using data from a cross-sectional study, we conducted correlations, binary and multivariable logistic regressions, and moderation analysis to explore relationships between COVID-19 vaccination and psychological variables. Of the 115 pregnant women, 64% reported receiving provider recommendations for COVID-19 vaccination. There were weak positive correlations between the variables. Participants with high anticipated regret scores were more likely to receive COVID-19 vaccination compared to their peers (AOR = 4.27; 95% CI, 1.23–14.85), while provider recommendation increased the odds of COVID-19 vaccination (OR = 3.70; 95% CI, 1.53–8.92). None of the HBM constructs were significantly associated with COVID-19 vaccination. The findings related to psychological variables require the reconceptualization of theory-informed interventions to streamline healthcare provision. The critical role of healthcare providers in COVID-19 vaccination recommendations suggests a need to empower health practitioners with effective communication skills to improve maternal health outcomes.
Full article
(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities 2.0)
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Open AccessArticle
Staff Resiliency in Long-Term Care during the COVID-19 Pandemic: A Qualitative Study
by
Behrouz Danesh, Shannon Freeman, Piper Jackson, Tammy Klassen-Ross, Alexandria Freeman-Idemilih and Davina Banner
COVID 2024, 4(6), 731-748; https://doi.org/10.3390/covid4060049 - 3 Jun 2024
Abstract
The COVID-19 pandemic has had a major impact on long-term care facilities (LTCFs). While much attention has been paid to the impact of the pandemic on residents, less attention has been given to the experiences of staff and factors impacting their resilience in
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The COVID-19 pandemic has had a major impact on long-term care facilities (LTCFs). While much attention has been paid to the impact of the pandemic on residents, less attention has been given to the experiences of staff and factors impacting their resilience in facing challenges working in LTCF. This research describes the factors contributing to the resiliency of LTCF staff during the COVID-19 pandemic in northern British Columbia (BC). Transcripts from 53 participants who completed one-hour semi-structured interviews were included and thematic analysis was conducted. All participants had experience working in a LTCF facility in northern BC during the pandemic. The LTCF staff described resilience as the ability to adapt to changing circumstances and protocols, while also maintaining a positive attitude and uplifting spirits during times of adversity. The analysis revealed five key themes influencing staff resilience: (1) availability and provision of resources for staff, (2) leadership and management within LTCFs, (3) social support available to staff, (4) impact of residents’ morale on staff resilience, and (5) personal attributes and characteristics of the staff. Understanding and addressing the five themes can guide the development of targeted strategies and interventions aimed at enhancing staff resilience and well-being during challenging circumstances. By recognizing and addressing the specific needs of LTCF staff, it is possible to improve the overall quality of care provided in LTCF and promote the well-being of both residents and staff. The findings shed light on the interplay of these themes and their profound influence on LTCF staff. Identifying staff’s needs and factors that contribute to their resilience may lower staff turnover, leading to a stronger and more resilient healthcare system, capable of safeguarding vulnerable populations, particularly during times of crisis such as the COVID-19 pandemic.
Full article
Open AccessArticle
A Qualitative Exploration of Factors Associated with COVID-19 Vaccine Uptake and Hesitancy in Selected Rural Communities in Kenya
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Fletcher Jiveti Njororai, Walter Amulla, Caleb Kogutu Nyaranga, Wilberforce Cholo and Toluwani Adekunle
COVID 2024, 4(6), 715-730; https://doi.org/10.3390/covid4060048 - 31 May 2024
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Purpose: The post-pandemic management of COVID-19 infections and any emergent outbreaks is because this endemic disease remains a public health concern. Vaccine hesitancy may continue to hamper efforts to respond to any new disease outbreaks and future epidemics. This qualitative study aimed to
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Purpose: The post-pandemic management of COVID-19 infections and any emergent outbreaks is because this endemic disease remains a public health concern. Vaccine hesitancy may continue to hamper efforts to respond to any new disease outbreaks and future epidemics. This qualitative study aimed to explore the factors influencing COVID-19 vaccine acceptance and hesitancy in Kenya to gain deeper insights into this issue. Methods: This study was implemented in western Kenya using key informant interviews. Fourteen (14) key informants were purposively selected for this study. All interviews were transcribed and analyzed using thematic analysis. The interpretation of findings was conducted within the framework of the Health Belief Model. Key findings: Knowledge was a critical factor in combatting misinformation and fostering vaccine acceptance among participants in this study. Misinformation included rumors that the vaccine lowers immunity and was intended for population control. Cues to action included influence from political and opinion leaders and observing the loss of life among unvaccinated individuals. Perceived barriers to vaccine uptake included fear of vaccine safety, side effects, long waiting times at the time of our study, fear of contracting COVID-19 at vaccination sites, family/spousal influence on vaccine uptake and fear of the unknown with the vaccine. Conclusions: The findings from this study provide insight into areas for targeted strategies for managing COVID-19 vaccinations and future pandemics. Within the framework of the Health Belief Model, this study identified salient barriers and facilitators of COVID-19 vaccine hesitancy that may be helpful to inform future pandemic responses.
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Open AccessArticle
An Energy-Optimized Artificial Intelligence of Things (AIoT)-Based Biosensor Networking for Predicting COVID-19 Outbreaks in Healthcare Systems
by
Monika Pahuja and Dinesh Kumar
COVID 2024, 4(6), 696-714; https://doi.org/10.3390/covid4060047 - 30 May 2024
Abstract
By integrating energy-efficient AIoT-based biosensor networks, healthcare systems can now predict COVID-19 outbreaks with unprecedented accuracy and speed, revolutionizing early detection and intervention strategies. Therefore, this paper explores the rapid growth of electronic technology in today’s environment, driven by the proliferation of advanced
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By integrating energy-efficient AIoT-based biosensor networks, healthcare systems can now predict COVID-19 outbreaks with unprecedented accuracy and speed, revolutionizing early detection and intervention strategies. Therefore, this paper explores the rapid growth of electronic technology in today’s environment, driven by the proliferation of advanced devices capable of monitoring and controlling various healthcare systems. However, these devices’ limited resources necessitate optimizing their utilization. To tackle this concern, we propose an enhanced Artificial Intelligence of Things (AIoT) system that utilizes the networking capabilities of IoT biosensors to forecast potential COVID-19 outbreaks. The system aims to efficiently collect data from deployed sensor nodes, enabling accurate predictions of possible disease outbreaks. By collecting and pre-processing diverse parameters from IoT nodes, such as body temperature (measured non-invasively using the open-source thermal camera TermoDeep), population density, age (captured via smartwatches), and blood glucose (collected via the CGM system), we enable the AI system to make accurate predictions. The model’s efficacy was evaluated through performance metrics like the confusion matrix, F1 score, precision, and recall, demonstrating the optimal potential of the IoT-based wireless sensor network for predicting COVID-19 outbreaks in healthcare systems.
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(This article belongs to the Special Issue Artificial Intelligence and Machine Learning Applications for Develo** the Diagnosis of COVID-19)
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Open AccessArticle
Computational Discovery of Novel Imidazole Derivatives as Inhibitors of SARS-CoV-2 Main Protease: An Integrated Approach Combining Molecular Dynamics and Binding Affinity Analysis
by
Benjamin Ayodipupo Babalola and Abayomi Emmanuel Adegboyega
COVID 2024, 4(6), 672-695; https://doi.org/10.3390/covid4060046 - 23 May 2024
Cited by 1
Abstract
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One of the most pressing challenges associated with SARS treatment is the emergence of new variants that may be transmissible, causing more severe disease or being resistant to the current standard of treatment. This study aimed to identify potential drug candidates from novel
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One of the most pressing challenges associated with SARS treatment is the emergence of new variants that may be transmissible, causing more severe disease or being resistant to the current standard of treatment. This study aimed to identify potential drug candidates from novel imidazole derivatives against SARS-CoV-2 main protease (Mpro), a crucial drug target for treating viral infection, using a computational approach that integrated molecular docking and dynamics simulation. In this study, we utilized AutoDock Vina within the PyRx workspace for molecular docking analysis to explore the inhibitory effects of the compounds on the Mpro, a drug target for SARS-CoV-2. The ADMET properties of these compounds, including absorption, distribution, metabolism, excretion, and toxicity, were evaluated using the SwissADME and ADMETLab servers. Each of the 18 compounds that were tested demonstrated strong binding affinities towards Mpro, with imidazolyl–methanone C10 showing the most significant binding affinity. Moreover, pyridyl–imidazole C5, thiophenyl–imidazole C1, and quinoline–imidazole C14 displayed binding affinities of −8.3, −8.2, and −7.7 Kcal/mol, respectively. These compounds interacted with specific amino acid residues (HIS A:41—CYS A:145) within the Mpro protein. To assess the stability of the ligand with the best binding affinity, molecular dynamics (MD) simulations were conducted using Schrodinger software, which revealed its stability over the simulation period. The study provides valuable insights into the potential of imidazole derivatives as SARS-CoV-2 Mpro inhibitors. All compounds including C10 display promising characteristics and hold potential as drug candidates for SARS-CoV-2. However, further optimization and experimental validation of these compounds are necessary to advance their development as effective therapeutics against viral infections.
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Open AccessArticle
How Political Ideology and Media Shaped Vaccination Intention in the Early Stages of the COVID-19 Pandemic in the United States
by
Dilshani Sarathchandra and Jennifer Johnson-Leung
COVID 2024, 4(5), 658-671; https://doi.org/10.3390/covid4050045 - 20 May 2024
Abstract
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As a pharmaceutical intervention, vaccines remain a major public health strategy for mitigating the effects of COVID-19. Yet, vaccine intake has been affected by various cognitive and cultural factors. We examine how a selected set of factors (i.e., knowledge, concern, media, peer influence,
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As a pharmaceutical intervention, vaccines remain a major public health strategy for mitigating the effects of COVID-19. Yet, vaccine intake has been affected by various cognitive and cultural factors. We examine how a selected set of factors (i.e., knowledge, concern, media, peer influence, and demographics) shaped COVID-19 vaccination intention in the early phase of the pandemic (Fall 2020). Using a survey conducted in three US states (Idaho, Texas, and Vermont) just prior to the rollout of the first vaccines against COVID-19, we find that COVID-19 concern was the primary driver of vaccination intention. Concern was shaped mainly by two factors: political ideology and media sources. Yet, ideology and media were much more important in affecting concern for those who leaned politically conservative, as opposed to those who leaned liberal or remained moderate. The results from our structural equation models affirm that the information politically conservative respondents were receiving reinforced the effects of their ideology, leading to a greater reduction in their concern. We discuss the potential implications of these findings for future pandemic preparedness.
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